As AI becomes increasingly powerful and ubiquitous, it is disrupting skills and displacing workers. NSF’s National AI Institute for Adult Learning and Online Education (AI-ALOE) posits that AI can be part of the solution to the growing problem if we can use AI for reskilling, upskilling, and workforce development at scale. The long-term vision of AI-ALOE is to develop and use AI technologies to enhance the proficiency of online education for all adult learners, using in-person education as a benchmark. The day-to-day mission of AI-ALOE is to conduct responsible research into AI that is grounded in theories of human cognition and learning and derived from the scientific process of learning engineering. I will describe ongoing research at AI-ALOE.