Single-electron transistors (SETs) provide current conduction characteristics comparable to CMOS technology and research shows that these devices can be used to develop logic circuits. It has been observed while building logic circuits that comprise only of SETs the voltage at the gate input had to be much higher than the power supply for the SET to have acceptable switching characteristics. This limitation in the gate and power supply voltages makes it practically inappropriate to build circuits. In this paper, we propose a hybrid architecture to overcome this limitation by combining conventional MOS devices with SETs. Three different types of hybrid circuits have been proposed and their characteristics have been studied using SPICE-based simulation tool which includes a SET-SPICE model.