Current theories of biologically inspired design assume that the design processes are domain independent. But is this assumption true? Design Study Library (DSL) is a digital library of eighty-three cases of biologically inspired design collected from a senior-level interdisciplinary class at Georgia Tech over 2006–2013. We describe a preliminary analysis of the DSL case studies. We posit that the assumption about the domain independence is questionable. In particular, some of the parameters in the domains of physiology and sensing appear to be different from the more common domains of mechanics and materials.